Articles Published in Professional Journals

Ｔ Sugimoto，H Das，S Imot， H Gomyo， S Chakraborty， R Tanigchi， T Isobe， T Nakagawa， R Nishimura， T Koizumi．　 Quantitation of Minimal Residual Disease in t(8;21)-Positive Acute Myelogenous Leukemia Patients Using Real-Time Quantitative RT-PCR. Am.J.Hematol.64,101-106,2000


S Imoto, Y Oomoto, K Murata, H Das, T Murayama, K Kajimoto, T Sugimoto, H Gomyo, T Nakagawa,R Nishimura, T Koizumi. Kinetics of Serum Cytokines After Allogeneic Bone Marrow Transplantation;Interleukin-5 as a Potential Marker of Acute Graft-Versus-Host Disease Int. J. Hematol.72,92-97,2000


H Das, S Imoto, T Murayama, I Mizuno, T Sugimoto, R Taniguchi, K Toda, T Isobe, T Nakagawa, R Nishimura, T Koizumi. Kinetic analysis of cytokine gene expression in patients with GVHD after donor lymphocyte infusion.
Bone marrow transplantation27,373-380,2001

Ｈ Matsuoka, T Murayama, T Koizumi, R Nishimura, R Kawaguchi, T Nakagawa. Establishment of a human myeloid cell line with trisomy 8 derived from overt leukemia following myelodysplastic syndrome. haematologica90,981-982,2005
　
村山　徹、水野石一、梶本和義、五明広志、中川俊太郎、西村隆一郎、小泉民雄
当院(兵庫県立成人病センター)における造血器腫瘍細胞株の樹立とその研究利用の可能性
第3回　日本臨床腫瘍学会総会　2005年3月

S. Tsuboi, T. Nakagawa, M. Tomita, T. Seo, H. Ono, K. Kawamura, and N.Iwamura Detection of Aflatoxin B１ in Serum Samples of Male Japanese Subjects by Radioimmunoassay and High-Performance Liquid Chromatography. Cancer Research 44: 1231-1234, 1984.

Y. Nakao, S. Matsuda, T. Matsui, T. Nakagawa, T. Fujita, T. Uchiyama, S. Maeda, Y. Okamoto, T. Masaoka, and Y. Ito Effect of Tumor Promoters on Human T Cell Leukemia/Lymhpoma Virus (HTLV)-Structural Protein Induction in Adult T-Cell Leukemia Cells. Cancer Letters 24: 129-139,1984.


Y. Nakao, S. Matsuda, T. Matsui, T. Nakagawa, T. Koizumi, T. Saida, and T. Fujita Phenotypic Changes Induced by a Novel Benzophenone Derivativeand Resultant Suppression of Cell Proliferation in the Human Thymic Acute Lymphoblastic Leukemia Cell Line HPB-ALL１. Cancer Research 44:5836-5844, 1984.


T. Nakagawa, Y. Nakao, T. Matsui, T. Koizumi, S. Matsuda, S. Maeda, and T. Fujita Effects of Sodium n-Butyrate on Alpha-Fetoprotein and Albumin　Secretion in the Human Hepatoma Cell Line.
PLC/PRF/5. Br. J. Cancer 51: 357-363, 1985.


T. Matsui, R. Takahashi, K. Mihara, T. Nakagawa, T. Koizumi, Y. Nakao, T. Sugiyama, and T. Fujita Cooperative Regulation of c-myc Expressionin Differentiation of Human Promyelocytic Leukemia Induced by Recombinant-Interferon and 1,25-Dihydroxyvitamin D３１. Cancer Res. 45:4366-4371,1985.


T. Matsui, Y. Nakao, T. Koizumi, T. Nakagawa, and T. Fujita 1,25-dihydroxyvitamin D３ Regulates Proliferation of Activated T-Lymphocyte Subsets. Life Science 37: 95-101, 1985.


T. Matsui,Y. Nakao, N. Kobayashi,T. Koizumi, T. Nakagawa,M. Kishihara, and T. Fujita Effects of Calmodulin Antagonists and Cytochalasins on Proliferation and Differentiation of Human Promyelocytic Lekumia Cell Line HL-60. Cancer Research 45:311-316, 1985.


T. Nakagawa, Y. Nakao, T. Matsui, T. Koizumi, S. Watanabe, and T. Fujita Effects of Alpha-Difluoromethyl Ornithyine on Alpha-Fetoprotein and Albumin Secretion in Human Hepatoma Cell Line, PLC/PRF/5. Cancer Letters28: 245-251, 1985.


T. Koizumi, Y. Nakao, T. Matsui, T. Nakagawa, S. Matsuda, K. Komoriya, Y. Kanai, and T. Fujita Effects of Corticosteroid and 1,24-Dihydroxy-vitamin D３ Administration on Lymphoproliferation and Autoimmune Disease in MRL/MP-1pr/1pr Mice. Int. Archs.Allergy Appl. Immun., 77(4): 396-404, 1985.


T. Koizumi, Y. Nakao, T. Matsui, Y. Katakami, T. Nakagawa, and T. Fujita SynergisticInduction by Calcium Ionophore and Phorbol Ester of Interleukin-2 (IL-2) Receptor Expression, IL-2 Production, and
Proliferation in Autoimmune MRL/MP-1pr Mice. Immunology 59: 43-49, 1986.


T. Nakagawa, M. Mabry, A. de Bustros, J.N. Ihle, B.D. Nelkin, and S.B. Baylin Introduction of v-Ha-ras Oncogene Induces Differentiation of Cultured Human Medullary Thyroid Carcinoma Cells. Proc. Natl. Acad. Sci.USA 84: 5923-5927, 1987.


Y. Nakao, T. Koizumi, T. Matsui, S. Matsuda,T. Nakagawa, Y. Katakami, T. Fujita, S. Maeda, S. Morikawa, and Y. Ito Effect of 1α,25-Dihydroxyvitamin D３ on Proliferation of Activated T-Cells and Established Human Lymphotropic Virus Type I-Positive T-Cell Lines. JNCI.78: 1079-1086, 1987.


M. Mabry, T. Nakagawa, B.D. Nelkin, E. McDowell, M. Gesell, J.C. Eggleston, R.A. Casero Jr., and S.B. Baylin v-Ha-ras Oncogene Insertion: A Model for Tumor Progression of Human Small Cell Lung Cancer. Proc. Natl. Acad. Sci. USA 85: 6523-6527, 1988.


T. Nakagawa, B.D. Nelkin, S.B. Baylin, and A. de Bustros Tran-scriptional and Posttranscriptional Modulation of Calcitonin Gene Expression by Sodium n-Butyrate in Cultured Human Medullary Thyroid
Carcinoma. Cancer Research 48: 2096-2100, 1988.


M. Mabry, T. Nakagawa, S. Baylin, O. Pettengill, G. Sorenson, and B. Nelkin Insertion the v-Ha-ras Oncogene Induces Differentiation of Calcitonin-producing Human Small　Cell Lung Cancer. J. Clin. Invest. 84:194-199, July 1989.



M.Watanabe, T.Sashikata, T.Kizaki, T.Fujiwara, K.Ugai, T.NakagawaA Case of Epidural Granulocytic Sarcoma Preceding Acute Leukemia. Acta. Pathologica .Japonica. 40, 922-926,1990.


T. Nakagawa, S. Saitoh, S. Imoto, M. Itoh, M. Tsutsumi, K. Hikiji, Y. Nakao, T. Fujita Loss of Multiple Point Mutations of Ras Genes Associated with Acquisition of Chromosomal Abnormalities During Disease Progression in
Myelodysplastic Syndrome. Br. J. Hematology.77:250-252,1991.


T. Nakagawa, S. Saitoh, S. Imoto, M. Itoh, M. Tsutsumi, K. Hikiji, H. Nakamura, S. Matozaki, R. Ogawa, Y.Nakao, T. Fujita Multiple Point Mutation of N-ras and K-ras Oncogenes in
Myelodysplastic Syndrome and Acute Myelogenous Leukemia. Oncology, vol.49, pp.114-122, 1992


M. Ito, S. Imoto, T. Nakagawa, A. Murotani, N. Tsubota . Spontaneous Remission in Pure Red Cell
Aplasia Associated with Thymoma . Int . J. Hematology, 54:209-212, 1991.


S. Matozaki, T. Nakagawa, Y. Nakao, T. Fujita Ras Gene Mutations in Multiple Myeloma and Related
Monoclonal Gammopathies. Kobe J. Med. Sci.37, 35-45, 1991.


T. Murayama, S. Imoto, T. Takahashi, M. Ito, S. Matozaki, T. Nakagawa, Successful Treatment
of Angioimmunoblastic Lymphadenopathy with Dysproteinemia by Cyclosporin. Cancer, 69,　2567-2570, 1992.


T. Murayama, S. Imoto, M. Ito, K. Matsushita, S. Matozaki, T. Nakagawa,Y. Kanbara, N. Kono, T. Sashikata, Mesenteric Fibromatosis Presentingas Fever of Unknown Origin. Amerikan Journal of Gastroenterology Vol.87 1503-1505 1992. 　　　　　　　　　　　　　　　　　　　　　　　　　　　　　


M.Tokisue, K.Yasutake, T. Nakagawa, and M. Kasuga . Genetic Changes in MultiStep Development of Colorectal Cancer. Kobe J. Med. Sci. 38,161-173,1992.


R.Kawaguchi, Y.Hosokawa, A.Komine, M.Tsutsumi, K.Hikiji, A.Ishida, K,Su-zuki,T.Nakagawa and K.Yamaguchi The Monocytic Cell Line SKM-1 Strong-ly Expresses the Myeloperoxidase Gene.
Leukemia,Vol6,1296-1301 1992.


T. Natazuka, T. Matsui, M. Ito, H. Nakata, T. Nakagawa, H. Nakamura, T. Masaoka, T. Isobe and Y. Nakao Rare point mutation at codon 301 and 969 of FMS/M-CSF receptor in acute myelomonocytic and monocytic leukemia.
Leuk.Res. 16,541-543, 1992.


T.Murayama, M.Ito, S.Imoto, K.Matsushita, S.Matozaki, T.Nakagawa. Idiopathic Thrombocytopenic Purpura With X Chromosome Abnormality. American J. Hematol. 42 239-240, 1993.


T.Nakagawa, S.Matozaki, T. Murayama, R.Nishimura, M. Tsutsumi, R. Kawaguchi, Y. Yokoyama, K. Hikiji, T. Isobe, and K. Chihara Establishment of a leukaemic cell line from a patient with acquisition of chromosomal
abnormalities during disease progression in myelodysplastic syndrome. Br. J Haematol 85 469-476 1993.


R.Kawaguchi, J.Yoshioka, K.Hikiji, T.Nakagawa, S.Matozaki, Y.Hosokawa, M.Totani, Expression of Myeloperoxidase mRNA in Newly Established Monoc-ytic and Myelocytic Human Cell Lines. Cancer Genetics and Cytogenetics Cancer Genet Cytogenet ,67,157,1993.


C.Sakakura, Y.Yamaguchi-Iwai, M.Satake, S.Bae, A.Takahashi, E.Ogawa, A.Hagiwara, T. Takahashi, A.Murakami, K.Makino, T.Nakagawa, N.Kamada, Y.Ito, Growth inhibition and induction of differentiation of t(8;21) acute myeloid leukemia cells by the DNA binding domain of PEBP2 and the AML1/MTG8(ETO) specific antisense oligonucleotide. Prc . Nat.. Acad. Sci. USA, 91, 11723-11727, 1994.


M.Yoshimura, R.Nishimura, A.Murotani, Y.Miyamoto, T.Nakagawa, K.Hasegawa, T.Koizumi, K.Shii,
S.Baba and N.Tsubota Assessment of Urinary Beta-Core Fragment of Human Chorionic Gonadotropin as a New Tumor Marker of Lung Cancer. Cancer. 73, 2745-2752, 1994.


S.Matozaki, T.Nakagawa, R. Kawaguchi, R.Aozaki, M. Tsutsumi,T. Murayama,T.Koizumi, R.Nishimura, T. Isobe, and K. Chihara Establishment of a myeloid leukaemic cell line（SKNO-1） from a patient with t(8;21) 　who acquired 17 monosomy during disease progression. Br. J. Haematol, 89, 805-811 ,1995.


T.Nakagawa, S.Matozaki, The SKM-1 Leukemic Cell Line Established From a Patient with Progression to Myelomonocytic Leukemia in Myelodysplastic Syndrome(MDS)-Contribution to Better Understanding of MDS. Leukemia and Lymphoma 17 335-339 1995.


T.Murayama, T.Nakagawa, K.Matsushita, S.Matozaki, K.Yasutake,T.Kizaki, T.Sashikata, Hemorrhagic colitis with unusual colonoscopy features complicated with chronic graft versus host disease after allogenic bone marrow transplantation. Bone marrow transplantation,15, 141-143. , 1995


R.Nishimura, T.Koizumi, K.Morisue N.Yamanaka, R.Lalwani, M.Yoshimura, T.Nakagawa, K.Shii. K.Hasegawa, S.Baba Expression and Secretion of the B Subunit of Human Chorionic Gonadotropin by Bladder Carcinoma in Vivo and in Vitro. Cancer Research 55, 1479-1484,1995.


Natazuka, T.　Ogawa, R.　Kizaki, T. Ueno, H. Shiotani, H. Koizumi T., Nishimura, R. Nakagawa, T. Immunosuppressive drugs and hypertrophic cardiomyopathy. LANCET 345,1644,1995.


M. Kinugasa, R. Nishimura, T. Koizumi, K. Morisue, T. Higashida, T. Natazuka, T. Nakagawa, T. Isobe, S. Baba, and K. Hasegawa. Combination Assay of Urinary B-Core Fragment of Human Chorionic Gonadotropin with Serum Tumor Markers in Gynecologic Cancers.　 J. J Cancer Res. 86, 783-789, 1995.


K.Yamazaki, K.Sato, K. Shizume, Y. Kanaji, Y. ITo, T. Obara, T. Nakagawa, T.Koizumi, R. Nishimura. Potent Thyrotropic Activity of Human Chorionic Gonadotropin Variants in Terms of 125 I Incorporation and de Novo Synthesized Thyroid Hormone Release in Human Thyroid Follicles. J. Clinical Endocrinol, 80,473-479, 1995.


Yokotani T, Koizumi T, Taniguchi R,Nakagawa T, Yoshimura M, Tsubota N, Hasegawa K, Ohsawa N, Baba S, Yasui H, Nishimura R Expression of α and β genes of human chorionic gonadotropin in lung cancer. Int. J. Cancer 71,539-544,1997.


Y. Yutsudo, S. Imoto, R. Ozuru, K. Kajimoto, H. Itoi, T.Koizumi, R.Nishimura, T.Nakagawa, Acute Pancreatitis after all-trans retinoic acid Therapy. Annals of Hematology, 74,295-296, 1997.


T. Natazuka, K. Kajimoto, R. Ogawa,S. Imoto, T. Koizumi, R. Nishimura, T. Nakagawa. Coagulation Abnormalities and Thrombotic Microangiopathy following Bone Marrow Transplantation from HLA-Matched Unrelated Donor in Patients with Hematological Malignancies. Bone marrow transplantation 21,815-819,1998.


H. Miyoshi, M. Ohki, T. Nakagawa, Y. Honma, Glcuocorticoids Induce Apoptosis in Acute Myeloid Leukemia Cell Lines with a t(8;21) Chromosome Translocation . Leukemia Research 21,45-50,1997.


K.Kishi, S. Takahashi, H. Gondo, S. Shiobara, R. Hanada, T. Matsue, M. Ohira, H. Kigasawa, A. Maruta, K. Ikuta, H. Yamada, Y. Morishita, S. Kageyama, K. Tsubaki, K. Kawa, T. Nakagawa, Y. Azuno, M. Hara, H. Tasaka, A.Kanamaru, S. Kato, N. Hirabayashi, Y. Moriyama, M. Harada, S. Asano, H. Hara, A. Shibata. Comparison of factors at second allogeneic bone marrow transplantation(BMT) for relapsed acute leukemia after BMT: Further analysis of 56 Cases from Japanese national survey. Int. J. Haemnatol, 1997.


F.Ohtsuki, M.Yamamoto, T.Nakagawa, T.Tanizawa, H.Wada. Granulocyte-macrophage colony-stimulating factor abrogates transforming growth factor-β1-mediated cell cycle arrest by up-regulating cyclin D2/Cdk6. Br. J .Haematol. 98,1997.


K.Kojima, T.Sawada, Y.Matsuo, H.Kobayashi, T.Yano, T.Sugimoto, S.Imoto, T.Nakagawa, T.Matsui, M.Yasukawa, M.Hara. H.Tguchi. Deleted HTLV-1 provirus from blood and lymphnode lesions of patients with T-cell prolymphocytic leukemia. Br.J.Haematol. 1999,105.376-381


Hiranmoy Das, Shion Imoto, T.Nakagawa, T.Koizumi, R.Nishimura. Levels of soluble FasL and FasL gene expression during the development of graft-versus-host disease in DLT-treated patient. Br. J. Haematol. 1999,104. 795-800.
　

Y Kodera, Y Morishima, S Kato, Y Akiyama, H sao, T Matsuyama, K Kawa, H Sakamaki, T Nakagawa, N Hirabayashi, H Dohi, S Okamoto,
A Hiraoka, H Gondo, M Tsuchida, H O, M Harada, S Asano, T juji, T Sasazuki, F Takaku. Analysis of 500 bone marrow transplants from unrelateddonors(UR-BMT) facilitated by the Japan Marrow Donor Program: confirmation of UR-BMT as a standard therapy for patients with leukemia and aplastic anemia. Bone marrow transplantation.24,995-1003,1999


T Murayama, T Koizumi, H Das, Y Kobayashi, K Kajimoto, T Sugimoto, S Imoto, T Nakagawa, R Nishimura. Soluble Fas Ligand in Natural killer Cell Lymphoma. Am.J.Hematol.62,253-255,1999